| Protein name |
Thaumatin |
| Host compatibility |
Komagatella phaffi (Pichia pastoris) |
| Yield |
0,03 g/L (Amanful et al., 2024)
|
| Scale (in specific example) |
Pilot scale (Amanful et al., 2024)
|
| Biggest scale product has been develloped in this organism |
Pilot scale (Amanful et al., 2024)
|
| Regulatory status in Europe |
Not allowed |
| Regulatory status in other parts of the world |
No FDA GRAS approval in US, not allowed in Canada |
| Companies producing this protein in this organism |
NA |
| Extra/remark |
Recombinant thaumatin is primarily being produced in plants (Kelada et al., 2021)
|
| Publications/references |
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Amanful, B., Dogbe, E. S., Bosman, C. E., & Görgens, J. F. (2024). Stochastic techno-economic analysis for the co-production of alternative sweeteners in sugarcane biorefineries. Food and Bioproducts Processing, 143, 9–20. https://doi.org/10.1016/j.fbp.2023.10.006
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Joseph, J. A., Akkermans, S., Nimmegeers, P., & Van Impe, J. F. M. (2019). Bioproduction of the Recombinant Sweet Protein Thaumatin: Current State of the Art and Perspectives. Frontiers in Microbiology, 10. https://doi.org/10.3389/fmicb.2019.00695
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Dalavi, M., Handge, S., Pate, V., Raut, H., Kakad, A., & Shaikh, M. (2024). Fundamental overview and applicability of thaumatin. International Journal of Pharmaceutical Chemistry and Analysis, 11(2), 153–159. https://doi.org/10.18231/j.ijpca.2024.021
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Farag, M. A., Rezk, M. M., Elashal, M. H., El-Araby, M., Khalifa, S. a. M., & El-Seedi, H. R. (2022). An updated multifaceted overview of sweet proteins and dipeptides as sugar substitutes; the chemistry, health benefits, gut interactions, and safety. Food Research International, 162, 111853. https://doi.org/10.1016/j.foodres.2022.111853
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Kelada, K. D., Tusé, D., Gleba, Y., McDonald, K. A., & Nandi, S. (2021). Process Simulation and Techno-Economic Analysis of Large-Scale Bioproduction of Sweet Protein Thaumatin II. Foods, 10(4), 838. https://doi.org/10.3390/foods10040838
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Asr, S. Y., Yüksel, N., İçi̇Er, S., & Türköz, B. K. (2022). Tatlı Bitkisel Proteinler ve Rekombinant Üretimleri. TüRk Doğa Ve Fen Dergisi :/TüRk Doğa Ve Fen Dergisi, 11(3), 186–194. https://doi.org/10.46810/tdfd.1027978
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Younes, M., Aquilina, G., Castle, L., Engel, K., Fowler, P., Fernandez, M. J. F., Fürst, P., Gürtler, R., Gundert‐Remy, U., Husøy, T., Manco, M., Mennes, W., Passamonti, S., Moldeus, P., Shah, R., Waalkens‐Berendsen, I., Wölfle, D., Wright, M., Batke, M., . . . Vianello, G. (2021). Re‐evaluation of thaumatin (E 957) as food additive. EFSA Journal, 19(11). https://doi.org/10.2903/j.efsa.2021.6884
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